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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   PRMT1 Antibody (C-term K342)   

PRMT1 Antibody (C-term K342)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PRMT1 Antibody (C-term K342) AP1001b
    Western blot analysis of anti-PRMT1 Antibody (C-term K342) (Cat.#AP1001b) in Hela cell line lysates (35ug/lane). PRMT1 (arrow) was detected using the purified Pab.
  • WB - PRMT1 Antibody (C-term K342) AP1001b
    PRMT1 Antibody (C-term K342) (Cat.#AP1001b) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the PRMT1 antibody detected the PRMT1 protein (arrow).
  • IHC-P - PRMT1 Antibody (C-term K342) AP1001b
    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with PRMT1 antibody (C-term K342), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99873
Other Accession Q63009, Q9JIF0
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41516 Da
Antigen Region 317-346 aa
Additional Information
Gene ID 3276
Other Names Protein arginine N-methyltransferase 1, 211-, Histone-arginine N-methyltransferase PRMT1, Interferon receptor 1-bound protein 4, PRMT1, HMT2, HRMT1L2, IR1B4
Target/Specificity This PRMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-346 amino acids from the C-terminal region of human PRMT1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRMT1 Antibody (C-term K342) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRMT1
Synonyms HMT2, HRMT1L2, IR1B4
Function Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity.
Cellular Location Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity).
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology.


Zhang, X., et al., EMBO J. 19(14):3509-3519 (2000).
Scorilas, A., et al., Biochem. Biophys. Res. Commun. 278(2):349-359 (2000).
Scott, H.S., et al., Genomics 48(3):330-340 (1998).
Abramovich, C., et al., EMBO J. 16(2):260-266 (1997).
Nikawa, J., et al., Gene 171(1):107-111 (1996).

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Cat# AP1001b
(40 western blots)
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