|Application ||WB, E|
|Reactivity||Human, Hamster, Mouse|
|Calculated MW||23114 Da|
|Antigen Region||54-83 aa|
|Other Names||A-kinase-interacting protein 1, Breast cancer-associated gene 3 protein, PKA-interacting protein, Proline-rich protein BCA3, AKIP1, BCA3, C11orf17|
|Target/Specificity||This BCA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 amino acids from the N-terminal region of human BCA3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCA3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.|
|Cellular Location||Nucleus. Note=Locates to punctate spots|
|Tissue Location||Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up- regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gao, N., et al. J. Biol. Chem. 285(36):28097-28104(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Gao, N., et al. J. Biol. Chem. 283(12):7834-7843(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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