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ABCC6 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP10101b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP10101b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ABCC6 Antibody (C-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | O95255 |
| Other Accession | NP_001162.4 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 164906 Da |
ABCC6 Antibody (C-term) - Additional info | |
| Gene ID 368 | |
| Other Names ABCC6; ARA; MRP6; Multidrug resistance-associated protein 6; ATP-binding cassette sub-family C member 6; Anthracycline resistance-associated protein; Multi-specific organic anion transporter E | |
| Target/Specificity This ABCC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1230-1260 amino acids from the C-terminal region of human ABCC6. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCC6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCC6 Antibody (C-term) - Protein Information | |
| Name ABCC6 | |
| Synonyms ARA, MRP6 | |
| Function May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) | |
| Cellular Location Membrane; Multi-pass membrane protein (By similarity). Note=Localized to the basolateral membrane | |
| Tissue Location Expressed in kidney and liver. Very low expression in other tissues | |
ABCC6 Antibody (C-term) - Related products
AP10101b: ABCC6 Antibody (C-term)
RI10024: ABCC6 predesign siRNA
BP10101b: ABCC6 Antibody (C-term) Blocking peptide
ABCC6 Antibody (C-term) - Application data
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ABCC6 Antibody (C-term) (Cat. #AP10101b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the ABCC6 antibody detected the ABCC6 protein (arrow).
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ABCC6 antibody (C-term) (Cat. #AP10101b) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the ABCC6 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
ABCC6 Antibody (C-term) - Research Areas
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BACKGROUND
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq].
REFERENCES
Zarbock, R., et al. Clin. Chim. Acta 411 (19-20), 1487-1490 (2010) : de Boussac, H., et al. J. Biol. Chem. 285(30):22800-22808(2010) Uitto, J., et al. J. Invest. Dermatol. 130(3):661-670(2010) Costrop, L.M., et al. J. Hum. Genet. 55(2):112-117(2010) Uitto, J. Trends Mol Med 11(8):341-343(2005)
