|Application ||WB, IHC-P, FC, E|
|Other Accession||NP_056362.1, NP_671517.1|
|Calculated MW||68492 Da|
|Antigen Region||549-575 aa|
|Other Names||Acyl-coenzyme A thioesterase 11, Acyl-CoA thioesterase 11, 312-, Acyl-CoA thioester hydrolase 11, Adipose-associated thioesterase, Brown fat-inducible thioesterase, BFIT, ACOT11, BFIT, KIAA0707, THEA|
|Target/Specificity||This ACOT11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-575 amino acids from the C-terminal region of human ACOT11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACOT11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BFIT, KIAA0707, THEA|
|Function||Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.|
|Tissue Location||Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung and brain Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants.
Kirkby, B., et al. Prog. Lipid Res. 49(4):366-377(2010)
Hunt, M.C., et al. J. Lipid Res. 46(9):2029-2032(2005)
Adams, S.H., et al. Biochem. J. 360 (PT 1), 135-142 (2001) :
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