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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   TNFRSF6B Antibody (N-term)   

TNFRSF6B Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TNFRSF6B Antibody (N-term) AP10136a
    TNFRSF6B Antibody (N-term) (Cat. #AP10136a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TNFRSF6B antibody detected the TNFRSF6B protein (arrow).
  • IHC-P - TNFRSF6B Antibody (N-term) AP10136a
    TNFRSF6B antibody (N-term) (Cat. #AP10136a) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TNFRSF6B antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - TNFRSF6B Antibody (N-term) AP10136a
    TNFRSF6B Antibody (N-term) (Cat. #AP10136a) flow cytometric analysis of 293 cells (right histogram) compared to a negative control (rabbit IgG alone) (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95407
Other Accession NP_116563.1, NP_003814.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 32680 Da
Antigen Region 22-48 aa
Additional Information
Gene ID 8771
Other Names Tumor necrosis factor receptor superfamily member 6B, Decoy receptor 3, DcR3, Decoy receptor for Fas ligand, M68, TNFRSF6B, DCR3, TR6
Target/Specificity This TNFRSF6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-48 amino acids from the N-terminal region of human TNFRSF6B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTNFRSF6B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DCR3, TR6
Function Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
Cellular Location Secreted.
Tissue Location Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells
Research Areas
Citations (0)

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This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Xiong, G., et al. Tumour Biol. 31(5):443-449(2010)
Sung, H.Y., et al. Int. J. Radiat. Biol. 86(9):780-790(2010)
Brunetti, G., et al. Ann. N. Y. Acad. Sci. 1192, 298-302 (2010) :
Perdigones, N., et al. Arthritis Rheum. 62(3):705-710(2010)

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Cat# AP10136a
(40 western blots)
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