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ABCC3 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP10144c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP10144c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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ABCC3 Antibody (Center) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | O15438 |
| Other Accession | NP_003777.2, NP_001137542.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 169343 Da |
ABCC3 Antibody (Center) - Additional info | |
| Gene ID 8714 | |
| Other Names ABCC3; CMOAT2; MLP2; MRP3; Canalicular multispecific organic anion transporter 2; ATP-binding cassette sub-family C member 3; Multi-specific organic anion transporter D; Multidrug resistance-associated protein 3 | |
| Target/Specificity This ABCC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 906-933 amino acids from the Central region of human ABCC3. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCC3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCC3 Antibody (Center) - Protein Information | |
| Name ABCC3 | |
| Synonyms CMOAT2, MLP2, MRP3 | |
| Function May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity) | |
| Cellular Location Membrane; Multi-pass membrane protein. | |
| Tissue Location Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney | |
ABCC3 Antibody (Center) - Related products
ABCC3 Antibody (Center) - Application data
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ABCC3 Antibody (Center) (Cat. #AP10144c) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ABCC3 antibody detected the ABCC3 protein (arrow).
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ABCC3 antibody (Center) (Cat. #AP10144c) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCC3 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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ABCC3 Antibody (Center) (Cat. #AP10144c) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ABCC3 Antibody (Center) - Research Areas
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BACKGROUND
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Hoffman, A.D., et al. Protein J. 29(5):373-379(2010) Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Moyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(3):811-821(2010)
