- CITATIONS: 1
|Application ||IHC-P, WB, E|
|Calculated MW||45349 Da|
|Antigen Region||368-396 aa|
|Other Names||Dimethyladenosine transferase 2, mitochondrial, 211-, Hepatitis C virus NS5A-transactivated protein 5, HCV NS5A-transactivated protein 5, Mitochondrial 12S rRNA dimethylase 2, Mitochondrial transcription factor B2, h-mtTFB, h-mtTFB2, hTFB2M, mtTFB2, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2, TFB2M, NS5ATP5|
|Target/Specificity||This TFB2M antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-396 amino acids from the C-terminal region of human TFB2M.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TFB2M Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.|
|Tissue Location||Ubiquitously expressed.|
Provided below are standard protocols that you may find useful for product applications.
Litonin, D., et al. J. Biol. Chem. 285(24):18129-18133(2010)
Norrbom, J., et al. Acta Physiol (Oxf) 198(1):71-79(2010)
Fukuoh, A., et al. Genes Cells 14(8):1029-1042(2009)
Cotney, J., et al. Hum. Mol. Genet. 18(14):2670-2682(2009)
Alonso-Montes, C., et al. Dis. Markers 25(3):131-139(2008)
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