|Application ||WB, FC, E|
|Calculated MW||93795 Da|
|Antigen Region||426-455 aa|
|Other Names||Glycerol-3-phosphate acyltransferase 1, mitochondrial, GPAT-1, GPAM, GPAT1, KIAA1560|
|Target/Specificity||This GPAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 426-455 amino acids from the Central region of human GPAM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPAM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.|
|Cellular Location||Mitochondrion outer membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Glycerol-3-phosphate acyltransferase (GPAT; EC 126.96.36.199), which catalyzes the initial and committing step in glycerolipid biosynthesis, is predicted to play a pivotal role in the regulation of cellular triacylglycerol and phospholipid levels. Two mammalian forms of GPAT have been identified on the basis of localization to either the endoplasmic reticulum or mitochondria.[supplied by OMIM].
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Chen, Y.Q., et al. J. Biol. Chem. 283(15):10048-10057(2008)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
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