- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||17843 Da|
|Antigen Region||126-155 aa|
|Other Names||Protein phosphatase 1 regulatory subunit 14C, Kinase-enhanced PP1 inhibitor, PKC-potentiated PP1 inhibitory protein, Serologically defined breast cancer antigen NY-BR-81, PPP1R14C, KEPI|
|Target/Specificity||This PP1R14C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-155 amino acids from the C-terminal region of human PP1R14C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PP1R14C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of the PP1 regulatory subunit PPP1CA.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Detected in breast cancer.|
Provided below are standard protocols that you may find useful for product applications.
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM].
Daskalow, K., et al. Anticancer Res. 30(5):1573-1578(2010)
Scholz, S.W., et al. Ann. Neurol. 65(5):610-614(2009)
Burgner, D., et al. PLoS Genet. 5 (1), E1000319 (2009) :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Liu, Q.R., et al. J. Biol. Chem. 277(15):13312-13320(2002)
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