|Application ||WB, IF, E|
|Other Accession||O35740, Q0VCT9, NP_001161860.1, NP_001161861.1, NP_006070.2|
|Calculated MW||28497 Da|
|Antigen Region||200-226 aa|
|Other Names||Cbp/p300-interacting transactivator 2, MSG-related protein 1, MRG-1, P35srj, CITED2, MRG1|
|Target/Specificity||This CITED2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-226 amino acids from the C-terminal region of human CITED2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CITED2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.|
|Cellular Location||Nucleus Note=Colocalizes with EP300 in dot-like structures|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of HIF1a to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Three transcript variants encoding the same protein have been found for this gene.
Yang, X.F., et al. Zhonghua Er Ke Za Zhi 48(4):293-296(2010)
Sun, H.B. Ann. N. Y. Acad. Sci. 1192, 429-436 (2010) :
Lau, W.M., et al. Int. J. Cancer 126(4):876-884(2010)
van Agthoven, T., et al. Br. J. Cancer 101(11):1824-1832(2009)
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
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