|Application ||WB, IF, E|
|Other Accession||O35740, Q0VCT9, NP_001161860.1, NP_001161861.1, NP_006070.2|
|Calculated MW||28497 Da|
|Antigen Region||200-226 aa|
|Other Names||Cbp/p300-interacting transactivator 2, MSG-related protein 1, MRG-1, P35srj, CITED2, MRG1|
|Target/Specificity||This CITED2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-226 amino acids from the C-terminal region of human CITED2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CITED2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.|
|Cellular Location||Nucleus Note=Colocalizes with EP300 in dot-like structures|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of HIF1a to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Three transcript variants encoding the same protein have been found for this gene.
Yang, X.F., et al. Zhonghua Er Ke Za Zhi 48(4):293-296(2010)
Sun, H.B. Ann. N. Y. Acad. Sci. 1192, 429-436 (2010) :
Lau, W.M., et al. Int. J. Cancer 126(4):876-884(2010)
van Agthoven, T., et al. Br. J. Cancer 101(11):1824-1832(2009)
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
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