|Application ||WB, IHC-P, FC, E|
|Other Accession||NP_001171951.1, NP_001298.3|
|Calculated MW||22418 Da|
|Antigen Region||172-201 aa|
|Other Names||Claudin-7, CLDN-7, CLDN7, CEPTRL2, CPETRL2|
|Target/Specificity||This CLDN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-201 amino acids from the C-terminal region of human CLDN7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLDN7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight junction. Note=Co- localizes with EPCAM at the lateral cell membrane and tight junction|
|Tissue Location||Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.
Kojima, F., et al. Oncol. Rep. 23(4):927-931(2010)
Rendon-Huerta, E., et al. J Gastrointest Cancer 41(1):52-59(2010)
Ouban, A., et al. Histol. Histopathol. 25(1):83-90(2010)
Kaarteenaho, R., et al. Respir. Res. 11, 59 (2010) :
Lal-Nag, M., et al. Genome Biol. 10 (8), 235 (2009) :
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