|Application ||WB, IHC-P, FC, IF, E|
|Other Accession||P56959, Q28009, NP_001164105.1|
|Calculated MW||53426 Da|
|Antigen Region||499-526 aa|
|Other Names||RNA-binding protein FUS, 75 kDa DNA-pairing protein, Oncogene FUS, Oncogene TLS, POMp75, Translocated in liposarcoma protein, FUS, TLS|
|Target/Specificity||This FUS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-526 amino acids from the C-terminal region of human FUS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FUS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
Kim, S.H., et al. J. Biol. Chem. 285(44):34097-34105(2010)
Mackenzie, I.R., et al. Lancet Neurol 9(10):995-1007(2010)
Yan, J., et al. Neurology 75(9):807-814(2010)
Waibel, S., et al. Neurology 75(9):815-817(2010)
Baumer, D., et al. Neurology 75(7):611-618(2010)
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