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DIS3 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP10196c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP10196c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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DIS3 Antibody (Center) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q9Y2L1 |
| Other Accession | NP_001121698.1, NP_055768.3 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 109003 Da |
DIS3 Antibody (Center) - Additional info | |
| Gene ID 22894 | |
| Other Names DIS3; KIAA1008; RRP44; Exosome complex exonuclease RRP44; Protein DIS3 homolog; Ribosomal RNA-processing protein 44 | |
| Target/Specificity This DIS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-331 amino acids from the Central region of human DIS3. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions DIS3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
DIS3 Antibody (Center) - Protein Information | |
| Name DIS3 | |
| Synonyms KIAA1008, RRP44 | |
| Function Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities | |
| Cellular Location Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in the nucleus According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3 | |
| Tissue Location Widely expressed. | |
DIS3 Antibody (Center) - Related products
DIS3 Antibody (Center) - Application data
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DIS3 Antibody (Center) (Cat. #AP10196c) western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the DIS3 antibody detected DIS3 protein (arrow).
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DIS3 antibody (Center) (Cat. #AP10196c) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DIS3 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
DIS3 Antibody (Center) - Research Areas
AntibodiesBiological ProcessMetabolic ProcessPrimary Metabolic ProcessCellular Metabolic ProcessCellular ProcessMacromolecule Metabolic ProcessCellular Macromolecule Metabolic ProcessCellular Component BiogenesisNitrogen Compound Metabolic ProcessCellular Nitrogen Compound Metabolic ProcessRNA Metabolic ProcessCellular CompartmentCytoplasmNucleolusNucleusIntracellular PartIntracellularMembrane-bounded OrganelleIntracellular Membrane-bounded OrganelleMembrane-enclosed LumenOrganelle LumenOrganelleIntracellular OrganelleIntracellular Organelle LumenOrganelle PartIntracellular Organelle PartNuclear LumenNuclear PartMacromolecular ComplexProtein ComplexMolecular FunctionCatalytic ActivityProtein BindingHydrolase Activity
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REFERENCES
Tomecki, R., et al. EMBO J. 29(14):2342-2357(2010) Andersen, J.S., et al. Nature 433(7021):77-83(2005) Lehner, B., et al. Genome Res. 14(7):1315-1323(2004) Dunham, A., et al. Nature 428(6982):522-528(2004) Scherl, A., et al. Mol. Biol. Cell 13(11):4100-4109(2002)
