|Application ||WB, IHC-P, E|
|Other Accession||O14715, Q99666, D3ZZL9, Q8CHG3, NP_852118.1|
|Calculated MW||195910 Da|
|Antigen Region||1581-1609 aa|
|Other Names||GRIP and coiled-coil domain-containing protein 2, 185 kDa Golgi coiled-coil protein, GCC185, CLL-associated antigen KW-11, CTCL tumor antigen se1-1, Ran-binding protein 2-like 4, RanBP2L4, Renal carcinoma antigen NY-REN-53, GCC2, KIAA0336, RANBP2L4|
|Target/Specificity||This GCC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1581-1609 amino acids from the C-terminal region of human GCC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GCC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.|
|Cellular Location||Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants.
Houghton, F.J., et al. Cell 138(4):787-794(2009)
Hayes, G.L., et al. Mol. Biol. Cell 20(1):209-217(2009)
Burguete, A.S., et al. Cell 132(2):286-298(2008)
Efimov, A., et al. Dev. Cell 12(6):917-930(2007)
Derby, M.C., et al. Traffic 8(6):758-773(2007)
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