|Application ||WB, FC, E|
|Other Accession||P36364, Q95L12, P54130, NP_002001.1|
|Calculated MW||23441 Da|
|Antigen Region||31-58 aa|
|Other Names||Fibroblast growth factor 9, FGF-9, Glia-activating factor, GAF, Heparin-binding growth factor 9, HBGF-9, FGF9|
|Target/Specificity||This FGF9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-58 amino acids from the N-terminal region of human FGF9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FGF9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.|
|Tissue Location||Glial cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis.
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Kalinina, J., et al. Mol. Cell. Biol. 29(17):4663-4678(2009)
Marroni, F., et al. Circ Cardiovasc Genet 2(4):322-328(2009)
Wu, X.L., et al. Am. J. Hum. Genet. 85(1):53-63(2009)
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