GGTLC2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q14390 |
Other Accession | B5MD39, A6NGU5, P36268, P07314, P20735, Q60928, P19440, NP_954578.2 |
Reactivity | Human |
Predicted | Mouse, Pig, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 23661 Da |
Antigen Region | 127-154 aa |
Gene ID | 91227 |
---|---|
Other Names | Gamma-glutamyltransferase light chain 2, Gamma-glutamyltransferase-like protein 4, GGTLC2, GGTL4 |
Target/Specificity | This GGTLC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-154 amino acids from the Central region of human GGTLC2. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GGTLC2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GGTLC2 |
---|---|
Synonyms | GGTL4 |
Tissue Location | Placenta and sigmoid tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC2, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM].
References
Heisterkamp, N., et al. Hum. Genet. 123(4):321-332(2008)
Dunham, I., et al. Nature 402(6761):489-495(1999)
Kawasaki, K., et al. Genome Res. 7(3):250-261(1997)
Leh, H., et al. FEBS Lett. 394(3):258-262(1996)
Wetmore, L.A., et al. Proc. Natl. Acad. Sci. U.S.A. 90(16):7461-7465(1993)
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