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MLXIP Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MLXIP Antibody (N-term) AP10228a
    MLXIP Antibody (N-term) (Cat. #AP10228a) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the MLXIP antibody detected the MLXIP protein (arrow).
    detail
  • IHC-P - MLXIP Antibody (N-term) AP10228a
    MLXIP antibody (N-term) (Cat. #AP10228a) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MLXIP antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q9HAP2
Other Accession Q2VPU4, NP_055753.3
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 101185 Da
Antigen Region 72-100 aa
Additional Information
Gene ID 22877
Other Names MLX-interacting protein, Class E basic helix-loop-helix protein 36, bHLHe36, Transcriptional activator MondoA, MLXIP (HGNC:17055)
Target/Specificity This MLXIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-100 amino acids from the N-terminal region of human MLXIP.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMLXIP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MLXIP (HGNC:17055)
Function Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Cellular Location Cytoplasm. Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Mitochondrion outer membrane Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}
Tissue Location Widely expressed in adult tissues. Most abundant in skeletal muscle.
Research Areas
Citations (0)
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Background

MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000 [PubMed 11073985]).

References

Peterson, C.W., et al. Mol. Cell. Biol. 30(12):2887-2895(2010)
Kaadige, M.R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(35):14878-14883(2009)
Stoltzman, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 105(19):6912-6917(2008)
Sans, C.L., et al. Mol. Cell. Biol. 26(13):4863-4871(2006)
Bornhauser, B.C., et al. J. Biol. Chem. 278(37):35412-35420(2003)

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$ 365.00
$ 140.00
Cat# AP10228a
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