|Application ||WB, FC, E|
|Other Accession||A6NM45, NP_001104789.1|
|Calculated MW||24509 Da|
|Antigen Region||90-117 aa|
|Other Names||Claudin-22, CLDN22|
|Target/Specificity||This CLDN22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids from the Central region of human CLDN22.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLDN22 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand.
Lal-Nag, M., et al. Genome Biol. 10 (8), 235 (2009) :
Krause, G., et al. Biochim. Biophys. Acta 1778(3):631-645(2008)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Katoh, M., et al. Int. J. Mol. Med. 11(6):683-689(2003)
Gonzalez-Mariscal, L., et al. Prog. Biophys. Mol. Biol. 81(1):1-44(2003)
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