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GAS2L1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q99501 |
| Other Accession | Q8JZP9, NP_689422.1, NP_689423.1, NP_006469.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 72717 Da |
| Antigen Region | 618-646 aa |
| Gene ID | 10634 |
|---|---|
| Other Names | GAS2-like protein 1, GAS2-related protein on chromosome 22, Growth arrest-specific protein 2-like 1, GAS2L1, GAR22 |
| Target/Specificity | This GAS2L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 618-646 amino acids from the C-terminal region of human GAS2L1. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GAS2L1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GAS2L1 |
|---|---|
| Synonyms | GAR22 |
| Function | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). |
| Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Note=Colocalizes with the tips of microtubule plus ends. |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene, a member of the GAS2 family, is similar in sequence to the mouse protein Gas2, an actin-associated protein expressed at high levels in growth-arrested cells. Expression of the mouse Gas2 gene is negatively regulated by serum and growth factors. Three transcript variants encoding two different isoforms have been found for this gene.
References
Saito, A., et al. Psychiatry Res (2010) In press :
Gamper, I., et al. Exp. Hematol. 37(5):539-548(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Goriounov, D., et al. J. Cell. Sci. 116 (PT 6), 1045-1058 (2003) :
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