|Application ||WB, IHC-P, E|
|Calculated MW||29574 Da|
|Antigen Region||77-106 aa|
|Other Names||Nicotinamide N-methyltransferase, NNMT|
|Target/Specificity||This NNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-106 amino acids from the Central region of human NNMT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NNMT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.|
|Tissue Location||Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas|
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Provided below are standard protocols that you may find useful for product applications.
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is the protein responsible for this enzymatic activity, which uses S-adenosyl methionine as the methyl donor.
Xu,J., Thyroid 16 (2), 151-160 (2006)
Roessler,M., Clin. Cancer Res. 11 (18), 6550-6557 (2005)
Souto,J.C., Am. J. Hum. Genet. 76 (6), 925-933 (2005)
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