|Application ||WB, IHC-P, E|
|Calculated MW||70105 Da|
|Antigen Region||462-490 aa|
|Other Names||Molybdenum cofactor biosynthesis protein 1, Cell migration-inducing gene 11 protein, Molybdenum cofactor synthesis-step 1 protein A-B, Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein A, Cyclic pyranopterin monophosphate synthase accessory protein, Molybdenum cofactor biosynthesis protein C, MOCS1|
|Target/Specificity||This MOCS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 462-490 amino acids from the C-terminal region of human MOCS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MOCS1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'- triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.|
|Tissue Location||Isoform MOCS1A and isoform 2 are widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000 [PubMed 11073985]).
Peterson, C.W., et al. Mol. Cell. Biol. 30(12):2887-2895(2010)
Kaadige, M.R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(35):14878-14883(2009)
Stoltzman, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 105(19):6912-6917(2008)
Sans, C.L., et al. Mol. Cell. Biol. 26(13):4863-4871(2006)
Bornhauser, B.C., et al. J. Biol. Chem. 278(37):35412-35420(2003)
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