- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Other Accession||Q9DAJ5, Q32P85, NP_570967.1|
|Calculated MW||10855 Da|
|Antigen Region||49-77 aa|
|Other Names||Dynein light chain roadblock-type 2, Dynein light chain 2B, cytoplasmic, Roadblock domain-containing protein 2, DYNLRB2, DNCL2B, DNLC2B, ROBLD2|
|Target/Specificity||This DYNLRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-77 amino acids from the Central region of human DYNLRB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DYNLRB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DNCL2B, DNLC2B, ROBLD2|
|Function||Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine; moderate in kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte|
Provided below are standard protocols that you may find useful for product applications.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)
Jin, Q., et al. J. Cell. Physiol. 221(3):707-715(2009)
Meyre, D., et al. Nat. Genet. 41(2):157-159(2009)
Pfister, K.K., et al. J. Cell Biol. 171(3):411-413(2005)
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