|Application ||WB, IHC-P, E|
|Other Accession||Q6P6N5, NP_001035987.1|
|Calculated MW||42670 Da|
|Antigen Region||31-59 aa|
|Other Names||Sprouty-related, EVH1 domain-containing protein 3, Spred-3, SPRED3, EVE-3|
|Target/Specificity||This SPRED3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-59 amino acids from the N-terminal region of human SPRED3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPRED3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase.|
|Cellular Location||Membrane; Peripheral membrane protein|
|Tissue Location||Expression is restricted to liver.|
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Provided below are standard protocols that you may find useful for product applications.
SPRED3 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).
King, J.A., et al. J. Hepatol. 44(4):758-767(2006)
Nonami, A., et al. J. Biol. Chem. 279(50):52543-52551(2004)
Mizoguchi, M., et al. Neurogenetics 5(1):81-82(2004)
Kato, R., et al. Biochem. Biophys. Res. Commun. 302(4):767-772(2003)
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