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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   JMJD1B Antibody (N-term)   

JMJD1B Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - JMJD1B Antibody (N-term) AP1027A
    Western blot analysis of anti-JMJD1B (N-term) Pab in Ramos cell line lysate. JMJD1B (N-term)(arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7LBC6
Other Accession Q6ZPY7
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 191581 Da
Antigen Region 25-57 aa
Additional Information
Gene ID 51780
Other Names Lysine-specific demethylase 3B, 11411-, JmjC domain-containing histone demethylation protein 2B, Jumonji domain-containing protein 1B, Nuclear protein 5qNCA, KDM3B, C5orf7, JHDM2B, JMJD1B, KIAA1082
Target/Specificity This JMJD1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-57 amino acids from the N-terminal region of human JMJD1B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsJMJD1B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM3B
Synonyms C5orf7, JHDM2B, JMJD1B, KIAA1082
Function Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
Cellular Location Nucleus.
Tissue Location Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver
Research Areas
Citations (0)

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Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.


Katoh, M., et al., Int. J. Mol. Med. 12(5):817-821 (2003).
Hu, Z., et al., Oncogene 20(47):6946-6954 (2001).
Lai, F., et al., Genomics 71(2):235-245 (2001).
Lai, F., et al., Genomics 70(1):123-130 (2000).
Dias Neto, E., et al., Proc. Natl. Acad. Sci. U.S.A. 97(7):3491-3496 (2000).

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$ 295.00
$ 99.00
Cat# AP1027A
(40 western blots)
Availability: In Stock
Bulk Size
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