|Application ||WB, FC, E|
|Other Accession||Q6AXQ5, Q3TIU4, Q08DF7, NP_808881.3|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||67352 Da|
|Antigen Region||362-390 aa|
|Other Names||2', 5'-phosphodiesterase 12, 2'-PDE, 2-PDE, 314-, Mitochondrial deadenylase, PDE12|
|Target/Specificity||This PDE12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 362-390 amino acids from the C-terminal region of human PDE12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.|
|Cellular Location||Mitochondrion matrix|
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Provided below are standard protocols that you may find useful for product applications.
Kohno, T., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 5), 520-522 (2010) :
Kubota, K., et al. J. Biol. Chem. 279(36):37832-37841(2004)
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