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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PDE12 Antibody (C-term)   

PDE12 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PDE12 Antibody (C-term) AP10288b
    PDE12 Antibody (C-term) (Cat. #AP10288b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PDE12 antibody detected the PDE12 protein (arrow).
  • FC - PDE12 Antibody (C-term) AP10288b
    PDE12 Antibody (C-term) (Cat. #AP10288b) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6L8Q7
Other Accession Q6AXQ5, Q3TIU4, Q08DF7, NP_808881.3
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 67352 Da
Antigen Region 362-390 aa
Additional Information
Gene ID 201626
Other Names 2', 5'-phosphodiesterase 12, 2'-PDE, 2-PDE, 314-, Mitochondrial deadenylase, PDE12
Target/Specificity This PDE12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 362-390 amino acids from the C-terminal region of human PDE12.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDE12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE12
Function Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
Cellular Location Mitochondrion matrix
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Kohno, T., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 5), 520-522 (2010) :
Kubota, K., et al. J. Biol. Chem. 279(36):37832-37841(2004)

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$ 295.00
$ 99.00
Cat# AP10288b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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