|Application ||WB, IHC-P, FC, E|
|Calculated MW||89590 Da|
|Antigen Region||658-687 aa|
|Other Names||Centrosomal protein of 89 kDa, Cep89, Centrosomal protein 123, Cep123, Coiled-coil domain-containing protein 123, CEP89, CCDC123|
|Target/Specificity||This CCDC123 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 658-687 amino acids from the C-terminal region of human CCDC123.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCDC123 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity.|
|Cellular Location||Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Mitochondrion intermembrane space. Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane|
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Provided below are standard protocols that you may find useful for product applications.
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Chambers, J.C., et al. Nat. Genet. 42(5):373-375(2010)
Hahn, Y., et al. Hum. Genet. 119 (1-2), 169-178 (2006) :
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