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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   LRRC33 Antibody (C-term)   

LRRC33 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - LRRC33 Antibody (C-term) AP10317b
    LRRC33 Antibody (C-term) (Cat. #AP10317b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the LRRC33 antibody detected the LRRC33 protein (arrow).
  • IHC-P - LRRC33 Antibody (C-term) AP10317b
    LRRC33 antibody (C-term) (Cat. #AP10317b) immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph node followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the LRRC33 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86YC3
Other Accession NP_940967.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 76366 Da
Antigen Region 611-640 aa
Additional Information
Gene ID 375387
Other Names Negative regulator of reactive oxygen species, Leucine-rich repeat-containing protein 33, NRROS, LRRC33
Target/Specificity This LRRC33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 611-640 amino acids from the C-terminal region of human LRRC33.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLRRC33 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms LRRC33
Function Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.
Cellular Location Cell membrane; Single-pass type I membrane protein Endoplasmic reticulum membrane; Single-pass type I membrane protein
Tissue Location Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen
Research Areas
Citations (0)

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Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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Cat# AP10317b
(40 western blots)
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