|Application ||WB, IHC-P, FC, E|
|Calculated MW||130501 Da|
|Antigen Region||1069-1097 aa|
|Other Names||Potassium channel subfamily T member 2, Sequence like an intermediate conductance potassium channel subunit, Sodium and chloride-activated ATP-sensitive potassium channel Slo21, KCNT2, SLICK|
|Target/Specificity||This KCNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1069-1097 amino acids from the C-terminal region of human KCNT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Santi, C.M., et al. J. Neurosci. 26(19):5059-5068(2006)
Wei, A.D., et al. Pharmacol. Rev. 57(4):463-472(2005)
Bhattacharjee, A., et al. J. Neurosci. 23(37):11681-11691(2003)
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