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KCNT2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - KCNT2 Antibody (C-term) AP10351b
    KCNT2 Antibody (C-term) (Cat. #AP10351b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the KCNT2 antibody detected the KCNT2 protein (arrow).
    detail
  • IHC-P - KCNT2 Antibody (C-term) AP10351b
    KCNT2 antibody (C-term) (Cat. #AP10351b) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the KCNT2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • FC - KCNT2 Antibody (C-term) AP10351b
    KCNT2 Antibody (C-term) (Cat. #AP10351b) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, IHC-P, WB, E
Primary Accession Q6UVM3
Other Accession NP_940905.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 130501 Da
Antigen Region 1069-1097 aa
Additional Information
Gene ID 343450
Other Names Potassium channel subfamily T member 2, Sequence like an intermediate conductance potassium channel subunit, Sodium and chloride-activated ATP-sensitive potassium channel Slo21, KCNT2, SLICK
Target/Specificity This KCNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1069-1097 amino acids from the C-terminal region of human KCNT2.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCNT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNT2
Synonyms SLICK
Function Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600). Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497).
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)
citation

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References

Santi, C.M., et al. J. Neurosci. 26(19):5059-5068(2006)
Wei, A.D., et al. Pharmacol. Rev. 57(4):463-472(2005)
Bhattacharjee, A., et al. J. Neurosci. 23(37):11681-11691(2003)

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$ 365.00
$ 140.00
Cat# AP10351b
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