- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Other Accession||A1A5Q0, Q3UHZ5, NP_997046.1|
|Calculated MW||61675 Da|
|Antigen Region||60-88 aa|
|Other Names||Leiomodin-2, Cardiac leiomodin, C-LMOD, LMOD2|
|Target/Specificity||This LMOD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-88 amino acids from the N-terminal region of human LMOD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LMOD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:26370058, PubMed:25250574, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713).|
|Cellular Location||Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere, M line Cytoplasm, cytoskeleton Note=Colocalizes with actin filaments in sarcomeres. Detected close to the M line.|
|Tissue Location||Specifically expressed in heart and skeletal muscles, with higher levels in heart (at protein level). Not expressed in other tissues.|
Provided below are standard protocols that you may find useful for product applications.
Chereau, D., et al. Science 320(5873):239-243(2008)
Lane, H.Y., et al. J Clin Psychopharmacol 26(2):128-134(2006)
Conley, C.A., et al. Genomics 73(2):127-139(2001)
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