|Application ||WB, IHC-P, E|
|Other Accession||NP_001161072.1, NP_542779.2, NP_001161074.1, NP_001161071.1, NP_001161073.1|
|Calculated MW||51572 Da|
|Antigen Region||423-452 aa|
|Other Names||Sialidase-4, N-acetyl-alpha-neuraminidase 4, NEU4|
|Target/Specificity||This NEU4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-452 amino acids from the C-terminal region of human NEU4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NEU4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids.|
|Cellular Location||Isoform 1: Membrane; Peripheral membrane protein|
|Tissue Location||Ubiquitous with higher expression in heart, skeletal muscle, liver and placenta|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Bigi, A., et al. Glycobiology 20(2):148-157(2010)
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)
Miyagi, T., et al. Proteomics 8(16):3303-3311(2008)
Stamatos, N.M., et al. FEBS J. 272(10):2545-2556(2005)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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