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ALX4 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP10386c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP10386c-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ALX4 Antibody (Center) - Product info | |
| Application | WB, FC
|
| Primary Accession | Q9H161 |
| Other Accession | O35137, Q4LAL6, NP_068745.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 44241 Da |
ALX4 Antibody (Center) - Additional info | |
| Gene ID 60529 | |
| Other Names ALX4; KIAA1788; Homeobox protein aristaless-like 4 | |
| Target/Specificity This ALX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-283 amino acids from the Central region of human ALX4. | |
| Dilution WB~~1:100~500WB~~1:1000 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ALX4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ALX4 Antibody (Center) - Protein Information | |
| Name ALX4 | |
| Synonyms KIAA1788 | |
| Function Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development | |
| Cellular Location Nucleus. | |
| Tissue Location Expression is likely to be restricted to bone. Found in parietal bone | |
ALX4 Antibody (Center) - Related products
ALX4 Antibody (Center) - Application data
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ALX4 Antibody (Center) (Cat. #AP10386c) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ALX4 antibody detected the ALX4 protein (arrow).
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ALX4 Antibody (Center) (Cat. #AP10386c) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ALX4 Antibody (Center) - Research Areas
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BACKGROUND
This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq].
REFERENCES
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) : Tanzer, M., et al. PLoS ONE 5 (2), E9061 (2010) : Kayserili, H., et al. Hum. Mol. Genet. 18(22):4357-4366(2009) Chang, H., et al. J. Clin. Pathol. 62(10):908-914(2009) Drenos, F., et al. Hum. Mol. Genet. 18(12):2305-2316(2009)
