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LCOR Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96JN0 |
| Other Accession | Q6ZPI3, NP_115816.2, NP_001164237.1, NP_001164236.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47007 Da |
| Antigen Region | 322-350 aa |
| Gene ID | 84458 |
|---|---|
| Other Names | Ligand-dependent corepressor, LCoR, Mblk1-related protein 2, LCOR, KIAA1795, MLR2 |
| Target/Specificity | This LCOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-350 amino acids from the C-terminal region of human LCOR. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LCOR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LCOR (HGNC:29503) |
|---|---|
| Function | May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000269|PubMed:12535528} |
| Tissue Location | Ubiquitous.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Palijan, A., et al. J. Biol. Chem. 284(44):30275-30287(2009)
Palijan, A., et al. J. Biol. Chem. 284(44):30264-30274(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
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