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>   home   >   Products   >   Primary Antibodies   >   JHDM1a/FBXL11 Antibody (Center)   

JHDM1a/FBXL11 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • IHC-P - JHDM1a/FBXL11 Antibody (Center) AP1043c
    Formalin-fixed and paraffin-embedded human testis tissue reacted with JHDM1a/FBXL11 antibody (Center) (Cat.#AP1043c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • WB - JHDM1a/FBXL11 Antibody (Center) AP1043c
    Western blot analysis of JHDM1a/FBXL11 (arrow) using rabbit polyclonal JHDM1a/FBXL11 Antibody (Center)(Cat.#AP1043c).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the JHDM1a/FBXL11 gene (Lane 2) (Origene Technologies).
  • WB - JHDM1a/FBXL11 Antibody (Center) AP1043c
    JHDM1a/FBXL11 Antibody (Center) (Cat.#AP1043c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the JHDM1a/FBXL11 antibody detected the JHDM1a/FBXL11 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y2K7
Other Accession P59997
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 132793 Da
Antigen Region 500-527 aa
Additional Information
Gene ID 22992
Other Names Lysine-specific demethylase 2A, CXXC-type zinc finger protein 8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, JmjC domain-containing histone demethylation protein 1A, [Histone-H3]-lysine-36 demethylase 1A, KDM2A, CXXC8, FBL7, FBXL11, JHDM1A, KIAA1004
Target/Specificity This JHDM1a/FBXL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-527 amino acids from the Central region of human JHDM1a/FBXL11.
Dilution IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsJHDM1a/FBXL11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM2A
Synonyms CXXC8, FBL7, FBXL11, JHDM1A, KIAA1004
Function Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
Cellular Location Nucleus, nucleoplasm Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2
Tissue Location Widely expressed, with highest levels in brain, testis and ovary, followed by lung
Citations (0)

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JHDM1a/FBXL11 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 6 highly degenerated leucine-rich repeats.


Tsukada,Y.,Nature 439 (7078), 811-816 (2006)
Andersen,J.S.,Nature 433 (7021), 77-83 (2005)

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Cat# AP1043c
(40 western blots)
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