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ABCD1 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP10454c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP10454c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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ABCD1 Antibody (Center) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | P33897 |
| Other Accession | P48410, NP_000024.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 82937 Da |
ABCD1 Antibody (Center) - Additional info | |
| Gene ID 215 | |
| Other Names ABCD1; ALD; ATP-binding cassette sub-family D member 1; Adrenoleukodystrophy protein | |
| Target/Specificity This ABCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-293 amino acids from the Central region of human ABCD1. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCD1 Antibody (Center) - Protein Information | |
| Name ABCD1 | |
| Synonyms ALD | |
| Function Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | |
| Cellular Location Peroxisome membrane; Multi-pass membrane protein | |
ABCD1 Antibody (Center) - Related products
AP10454c: ABCD1 Antibody (Center)
ABCD1 Antibody (Center) - Application data
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ABCD1 Antibody (Center) (Cat. #AP10454c) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ABCD1 antibody detected the ABCD1 protein (arrow).
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ABCD1 antibody (Center) (Cat. #AP10454c) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCD1 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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ABCD1 Antibody (Center) (Cat. #AP10454c) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ABCD1 Antibody (Center) - Research Areas
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BACKGROUND
ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.
REFERENCES
Matsukawa, T., et al. Neurogenetics (2010) In press : Xie, H.H., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(2):144-148(2010) Li, J.Y., et al. J. Neurol. Sci. 290 (1-2), 163-165 (2010) : Hour, T.C., et al. Int. J. Biol. Markers 24(3):171-178(2009) Shukla, P., et al. J. Child Neurol. 24(7):857-860(2009)
