|Application ||WB, FC, E|
|Other Accession||A2AWA9, NP_036329.3|
|Calculated MW||121737 Da|
|Antigen Region||14-43 aa|
|Other Names||Rab GTPase-activating protein 1, GAP and centrosome-associated protein, Rab6 GTPase-activating protein GAPCenA, RABGAP1|
|Target/Specificity||This RABGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human RABGAP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RABGAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition.|
|Cellular Location||Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly cytosolic but also associated with the centrosome|
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Provided below are standard protocols that you may find useful for product applications.
RABGAP1 may act as a GTPase-activating protein of RAB6A and play a role in microtubule nucleation by centrosome. It may participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)
Echard, A., et al. Mol. Biol. Cell 11(11):3819-3833(2000)
Opdam, F.J., et al. J. Cell. Sci. 113 (PT 15), 2725-2735 (2000) :
Cuif, M.H., et al. EMBO J. 18(7):1772-1782(1999)
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