|Application ||WB, FC, E|
|Calculated MW||52992 Da|
|Antigen Region||55-81 aa|
|Other Names||Leukocyte immunoglobulin-like receptor subfamily A member 2, CD85 antigen-like family member H, Immunoglobulin-like transcript 1, ILT-1, Leukocyte immunoglobulin-like receptor 7, LIR-7, CD85h, LILRA2, ILT1, LIR7|
|Target/Specificity||This LILRA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-81 amino acids from the Central region of human LILRA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LILRA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Does not bind class I MHC antigens (PubMed:19230061). Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells (PubMed:9548455). Detected in eosinophils, neutrophils and monocytes (PubMed:12529506)|
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Provided below are standard protocols that you may find useful for product applications.
Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.
Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Jones, D.C., et al. Eur. J. Immunol. 39(11):3195-3206(2009)
Chen, Y., et al. J. Mol. Biol. 386(3):841-853(2009)
Mamegano, K., et al. Genes Immun. 9(3):214-223(2008)
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