|Application ||WB, FC, E|
|Calculated MW||52992 Da|
|Antigen Region||55-81 aa|
|Other Names||Leukocyte immunoglobulin-like receptor subfamily A member 2, CD85 antigen-like family member H, Immunoglobulin-like transcript 1, ILT-1, Leukocyte immunoglobulin-like receptor 7, LIR-7, CD85h, LILRA2, ILT1, LIR7|
|Target/Specificity||This LILRA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-81 amino acids from the Central region of human LILRA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LILRA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Does not bind class I MHC antigens (PubMed:19230061). Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells (PubMed:9548455). Detected in eosinophils, neutrophils and monocytes (PubMed:12529506)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.
Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Jones, D.C., et al. Eur. J. Immunol. 39(11):3195-3206(2009)
Chen, Y., et al. J. Mol. Biol. 386(3):841-853(2009)
Mamegano, K., et al. Genes Immun. 9(3):214-223(2008)
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