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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   SELPLG Antibody (C-term)   

SELPLG Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SELPLG Antibody (C-term) AP10468b
    SELPLG Antibody (C-term) (Cat. #AP10468b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the SELPLG antibody detected the SELPLG protein (arrow).
  • FC - SELPLG Antibody (C-term) AP10468b
    SELPLG Antibody (C-term) (Cat. #AP10468b) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q14242
Other Accession NP_002997.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 43201 Da
Antigen Region 379-405 aa
Additional Information
Gene ID 6404
Other Names P-selectin glycoprotein ligand 1, PSGL-1, Selectin P ligand, CD162, SELPLG
Target/Specificity This SELPLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 379-405 amino acids from the C-terminal region of human SELPLG.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSELPLG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SELPLG
Function A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed on neutrophils, monocytes and most lymphocytes
Research Areas
Citations (0)

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Background

SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters.

References

Elmas, E., et al. J. Cardiovasc. Electrophysiol. 21(11):1260-1265(2010)
Luan, S.L., et al. J. Pathol. 222(2):166-179(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Russo, H.M., et al. Circ. Res. 107(3):388-397(2010)
Dick, D.M., et al. Mol. Psychiatry (2010) In press :

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$ 295.00
$ 99.00
Cat# AP10468b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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