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BCMO1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BCMO1 Antibody (Center) AP10472c
    BCMO1 Antibody (Center) (Cat. #AP10472c) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the BCMO1 antibody detected the BCMO1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HAY6
Other Accession NP_059125.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 62637 Da
Antigen Region 263-292 aa
Additional Information
Gene ID 53630
Other Names Beta, beta-carotene 15, 15'-monooxygenase, Beta-carotene dioxygenase 1, Beta-carotene oxygenase 1 {ECO:0000312|HGNC:HGNC:13815}, BCO1 (HGNC:13815)
Target/Specificity This BCMO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the Central region of human BCMO1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBCMO1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCO1 (HGNC:13815)
Function Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.
Tissue Location Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon.
Research Areas
Citations (0)

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Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules.


Lietz, G., et al. Arch. Biochem. Biophys. 502(1):8-16(2010)
Kim, Y.S., et al. Biotechnol. Lett. 32(6):847-853(2010)
Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)
Perry, J.R., et al. Diabetologia 52(10):2117-2121(2009)
Ferrucci, L., et al. Am. J. Hum. Genet. 84(2):123-133(2009)

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Cat# AP10472c
(40 western blots)
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