|Application ||WB, IHC-P, E|
|Calculated MW||115221 Da|
|Antigen Region||144-170 aa|
|Other Names||Collagen alpha-1(XIX) chain, Collagen alpha-1(Y) chain, COL19A1|
|Target/Specificity||This COL19A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-170 amino acids from the N-terminal region of human COL19A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COL19A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord|
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Provided below are standard protocols that you may find useful for product applications.
COL19A1 encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :
Boudko, S.P., et al. J. Biol. Chem. 283(49):34345-34351(2008)
Kapyla, J., et al. J. Biol. Chem. 279(49):51677-51687(2004)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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