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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   INPP5B Antibody (C-term)   

INPP5B Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - INPP5B Antibody (C-term) AP10490b
    INPP5B Antibody (C-term) (Cat. #AP10490b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the INPP5B antibody detected the INPP5B protein (arrow).
  • IHC-P - INPP5B Antibody (C-term) AP10490b
    INPP5B antibody (C-term) (Cat. #AP10490b) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the INPP5B antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - INPP5B Antibody (C-term) AP10490b
    INPP5B Antibody (C-term) (Cat. #AP10490b) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P32019
Other Accession NP_005531.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 112852 Da
Antigen Region 950-979 aa
Additional Information
Gene ID 3633
Other Names Type II inositol 1, 5-trisphosphate 5-phosphatase, 75 kDa inositol polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase, 5PTase, INPP5B, OCRL2
Target/Specificity This INPP5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 950-979 amino acids from the C-terminal region of human INPP5B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsINPP5B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms OCRL2
Function Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
Cellular Location Cytoplasm, cytosol. Endoplasmic reticulum- Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane. Golgi apparatus
Tissue Location Platelets.
Research Areas
Citations (0)

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Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). INPP5B encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].


Coon, B.G., et al. Hum. Mol. Genet. 18(23):4478-4491(2009)
Mao, Y., et al. EMBO J. 28(13):1831-1842(2009)
Williams, C., et al. J. Cell. Sci. 120 (PT 22), 3941-3951 (2007) :
Speed, C.J., et al. Eur. J. Biochem. 234(1):216-224(1995)
Janne, P.A., et al. Genomics 28(2):280-285(1995)

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Cat# AP10490b
(40 western blots)
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