|Application ||WB, IHC-P, E|
|Calculated MW||26584 Da|
|Antigen Region||164-193 aa|
|Other Names||Tryptase delta, Delta-tryptase, HmMCP-3-like tryptase III, Mast cell mMCP-7-like, Tryptase-3, TPSD1|
|Target/Specificity||This TPSD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-193 amino acids from the C-terminal region of human TPSD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TPSD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.|
|Cellular Location||Secreted. Note=Released from the secretory granules upon mast cell activation.|
|Tissue Location||Expressed in colon, lung, heart and synovial tissue. May be specific to mast cells|
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Provided below are standard protocols that you may find useful for product applications.
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. TPSD1 was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein.
Jackson, N.E., et al. J. Biol. Chem. 283(49):34178-34187(2008)
Caughey, G.H. J. Allergy Clin. Immunol. 117(6):1411-1414(2006)
Wang, H.W., et al. J. Immunol. 169(9):5145-5152(2002)
Caughey, G.H. Mol. Immunol. 38 (16-18), 1353-1357 (2002) :
Soto, D., et al. Clin. Exp. Allergy 32(7):1000-1006(2002)
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