DEN5A Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
---|---|
Primary Accession | Q6IQ26 |
Other Accession | Q6PAL8, NP_056028.2, G3V7Q0 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 147096 Da |
Antigen Region | 695-724 aa |
Gene ID | 23258 |
---|---|
Other Names | DENN domain-containing protein 5A, Rab6-interacting protein 1, Rab6IP1, DENND5A, KIAA1091, RAB6IP1 |
Target/Specificity | This DEN5A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 695-724 amino acids from the Central region of human DEN5A. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DEN5A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DENND5A |
---|---|
Synonyms | KIAA1091, RAB6IP1 |
Function | Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). |
Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6PAL8} |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in Rab6-mediated GTPase signaling.
References
Recacha, R., et al. Structure 17(1):21-30(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Janoueix-Lerosey, I., et al. J. Biol. Chem. 270(24):14801-14808(1995)
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