NDUAB Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q86Y39 |
Other Accession | NP_783313.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 14852 Da |
Antigen Region | 64-92 aa |
Gene ID | 126328 |
---|---|
Other Names | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11, Complex I-B147, CI-B147, NADH-ubiquinone oxidoreductase subunit B147, NDUFA11 |
Target/Specificity | This NDUAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the Central region of human NDUAB. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NDUAB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NDUFA11 |
---|---|
Function | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. |
Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side |
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Provided below are standard protocols that you may find useful for product applications.
Background
NDUFA11 encodes a subunit of the membrane-bound mitochondrial complex I. Complex I is composed of numerous subunits and functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain. Mutations in this gene are associated with severe mitochondrial complex I deficiency. Alternate splicing results in multiple transcript variants.
References
Berger, I., et al. Ann. Neurol. 63(3):405-408(2008)
Takagaki, K., et al. Biochem. Biophys. Res. Commun. 309(2):351-358(2003)
Murray, J., et al. J. Biol. Chem. 278(16):13619-13622(2003)
Carroll, J., et al. J. Biol. Chem. 277(52):50311-50317(2002)
Carroll, J., et al. J. Biol. Chem. 277(52):50311-50317(2002)
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