WWC3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q9ULE0 |
Other Accession | NP_056506.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 136649 Da |
Antigen Region | 1008-1037 aa |
Gene ID | 55841 |
---|---|
Other Names | Protein WWC3, WWC3, KIAA1280 |
Target/Specificity | This WWC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1008-1037 amino acids from the C-terminal region of human WWC3. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | WWC3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | WWC3 |
---|---|
Synonyms | KIAA1280 |
Function | Negative regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. |
Cellular Location | Cytoplasm, cytosol. |
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Provided below are standard protocols that you may find useful for product applications.
References
Kimura, K., et al. Genome Res. 16(1):55-65(2006)
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