|Application ||WB, FC, E|
|Calculated MW||51438 Da|
|Antigen Region||126-154 aa|
|Other Names||5-hydroxytryptamine receptor 3E, 5-HT3-E, 5-HT3E, Serotonin receptor 3E, HTR3E|
|Target/Specificity||This 5HT3E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-154 amino acids from the Central region of human 5HT3E.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||5HT3E Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A|
|Tissue Location||Expressed in adult colon and intestine.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. HTR3E encodes a subunit E of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. An alternative splice variant has been described but its full length sequence has not been determined.
Walstab, J., et al. J. Biol. Chem. 285(35):26956-26965(2010)
Hammer, C., et al. Pharmacogenomics 11(7):943-950(2010)
Lennertz, L., et al. Eur Neuropsychopharmacol 20(6):414-420(2010)
Goecke, T.W., et al. Acta Obstet Gynecol Scand 89(1):7-14(2010)
Schuhmacher, A., et al. Pharmacogenet. Genomics 19(11):843-851(2009)
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