|Application ||WB, IHC-P, E|
|Calculated MW||59374 Da|
|Antigen Region||390-418 aa|
|Other Names||Coiled-coil domain-containing protein 8, CCDC8|
|Target/Specificity||This CCDC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human CCDC8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCDC8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome|
|Tissue Location||Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver|
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Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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