|Application ||WB, FC, E|
|Other Accession||NP_878910.1, NP_006335.2|
|Calculated MW||35446 Da|
|Antigen Region||1-30 aa|
|Other Names||C-type lectin domain family 10 member A, C-type lectin superfamily member 14, Macrophage lectin 2, CD301, CLEC10A, CLECSF13, CLECSF14, HML|
|Target/Specificity||This CLEC10A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CLEC10A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLEC10A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLECSF13, CLECSF14, HML|
|Function||Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
CLEC10A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Iijima, M., et al. Neurology 73(17):1348-1352(2009)
van Vliet, S.J., et al. PLoS Pathog. 5 (10), E1000625 (2009) :
Suzuki, N., et al. J. Immunol. 156(1):128-135(1996)
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