|Application ||WB, IHC-P, E|
|Calculated MW||111898 Da|
|Antigen Region||947-975 aa|
|Other Names||RAS protein activator like-3, RASAL3|
|Target/Specificity||This RASAL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 947-975 amino acids from the C-terminal region of human RASAL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RASAL3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway.|
|Cellular Location||Cytoplasm. Cytoplasm, cell cortex|
|Tissue Location||Predominantly expressed in cells of hematopoietic lineages.|
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May functions as a Ras GTPase-activating protein (By similarity).
Kimura, K., et al. Genome Res. 16(1):55-65(2006)
Ota, T., et al. Nat. Genet. 36(1):40-45(2004)
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