|Application ||WB, E|
|Other Accession||Q8K1S6, NP_115827.1|
|Calculated MW||79671 Da|
|Antigen Region||285-313 aa|
|Other Names||Protein spire homolog 2, Spir-2, SPIRE2, KIAA1832, SPIR2|
|Target/Specificity||This SPIRE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-313 amino acids from the Central region of human SPIRE2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPIRE2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion.|
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Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in vesicle transport processes providing a novel link between actin organization and intracellular transport (By similarity).
Pechlivanis, M., et al. J. Biol. Chem. 284(37):25324-25333(2009)
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