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Mouse Dnmt2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | O55055 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46794 Da |
| Antigen Region | 201-230 aa |
| Gene ID | 13434 |
|---|---|
| Other Names | tRNA (cytosine(38)-C(5))-methyltransferase, DNA (cytosine-5)-methyltransferase-like protein 2, Dnmt2, DNA methyltransferase homolog MmuIIP, DNA MTase homolog MmuIIP, MMmuIIP, Met-2, Trdmt1, Dnmt2, Met2 |
| Target/Specificity | This Mouse Dnmt2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the N-terminal region of mouse Dnmt2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Dnmt2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Trdmt1 |
|---|---|
| Synonyms | Dnmt2 {ECO:0000303|PubMed:16424344}, Met |
| Function | Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:21183079, PubMed:22885326, PubMed:26271101). Has higher activity on tRNA(Asp) modified with queuosine at position 34 (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O14717}. |
| Tissue Location | Highly expressed in thymus, testis, and at much lower levels in spleen, lung, brain, heart, kidney, liver, skeletal muscle and embryonic stem cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
mDnmt2 does not appear to be active as a DNA methyltransferase; however, its strong binding to DNA suggests that it may mark specific sequences in the genome by binding to DNA through the specific target-recognizing motif. mDnmt2 is strongly expressed in thymus, testis, and at much lower levels in spleen, lung, brain, heart, kidney, liver, skeletal muscle and embryonic stem cells. This protein belongs to the 5-cystosine methyltransferase family.
References
Yoder, J.A., et al., Hum. Mol. Genet. 7(2):279-284 (1998).
Okano, M., et al., Nucleic Acids Res. 26(11):2536-2540 (1998).
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